Serum samples: blood samples from healthy male and female donors were obtained by venotomy. Serum collected from the clotted samples and free of hemolysis
نویسندگان
چکیده
Complement, Electron Spin Resonance, Free Radicals We describe the appearance of a free-radical signal in the ESR spectrum of normal human serum incubated with several complement activating agents. The intensity of this signal is dependent of dose of activating agents, time and temperature. Signals elicited by different complement activators differ in morphology and kinetics. Inhibition by treatment with EDTA and the presence of the signal in activated C 6-deficient rabbit serum suggest that the convertase forming steps of complement activation (C2 to 5) could be the source of free-radical containing molecules.
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